Anti-Protein Kinase A regulatory subunit I alpha 抗体 [6C7] (ab118061)

製品の概要

  • 製品名Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7]
    Protein Kinase A regulatory subunit I alpha 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [6C7] to Protein Kinase A regulatory subunit I alpha
  • アプリケーション適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant Human Protein Kinase A regulatory subunit I alpha protein expressed in 293T cells.

  • ポジティブ・コントロール
    • HEK293T cell lysate transfected with pCMV6-ENTRY Protein Kinase A regulatory subunit I alpha cDNA; HeLa, HT29, A549 and Jurkat cell extracts; Human breast adenocarcinoma, bladder carcinoma, colon, endometrium, ovary and prostate tissues; COS7 cells transiently transfected by pCMV6-ENTRY Protein Kinase A regulatory subunit I alpha.
  • 特記事項Stable for 12 months from date of receipt.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Predicted molecular weight: 43 kDa.
IHC-P 1/50.
ICC/IF 1/100.

ターゲット情報

  • 組織特異性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 関連疾患Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
    Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
    Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.
  • 配列類似性Belongs to the cAMP-dependent kinase regulatory chain family.
    Contains 2 cyclic nucleotide-binding domains.
  • 翻訳後修飾The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ACRDYS1 antibody
    • ADOHR antibody
    • cAMP dependent protein kinase regulatory subunit alpha 1 antibody
    • cAMP dependent protein kinase regulatory subunit RIalpha antibody
    • cAMP dependent protein kinase type I alpha regulatory chain antibody
    • cAMP dependent protein kinase type I alpha regulatory subunit antibody
    • cAMP-dependent protein kinase type I-alpha regulatory subunit antibody
    • CAR antibody
    • Carney complex type 1 antibody
    • CNC 1 antibody
    • CNC antibody
    • CNC1 antibody
    • DKFZp779L0468 antibody
    • KAP0_HUMAN antibody
    • MGC17251 antibody
    • PKA RIA antibody
    • PKR 1 antibody
    • PKR1 antibody
    • PPNAD 1 antibody
    • PPNAD1 antibody
    • PRKAR 1 antibody
    • PRKAR1 antibody
    • PRKAR1A antibody
    • PRKAR1A/RARA FUSION GENE antibody
    • Protein kinase A type 1a regulatory subunit antibody
    • Protein kinase cAMP dependent regulatory type I alpha antibody
    • PTC2 CHIMERIC ONCOGENE, INCLUDED antibody
    • Tissue specific extinguisher 1 antibody
    • Tissue-specific extinguisher 1 antibody
    • TSE 1 antibody
    • TSE1 antibody
    see all

Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] 画像

  • All lanes : Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] (ab118061) at 1/2000 dilution

    Lane 1 : HEK293T cell lysate, transfected with the pCMV6-ENTRY control cDNA
    Lane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY Protein Kinase A regulatory subunit I alpha cDNA

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 43 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC201638)
  • All lanes : Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] (ab118061) at 1/2000 dilution

    Lane 1 : HEK293 cell extract
    Lane 2 : HeLa cell extract
    Lane 3 : HT29 cell extract
    Lane 4 : A549 cell extract
    Lane 5 : COS7 cell extract
    Lane 6 : Jurkat cell extract
    Lane 7 : MDCK cell extract
    Lane 8 : PC12 cell extract
    Lane 9 : MCF7 cell extract

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 43 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC201601)
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Breast adenocarcinoma tissue by Immunohistochemistry.
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Colon tissue by Immunohistochemistry.
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Ovary tissue by Immunohistochemistry.
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Endometrium tissue by Immunohistochemistry.
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab118061 at 1/50 dilution staining Protein Kinase A regulatory subunit I alpha in Paraffin-embedded Human Bladder carcinoma tissue by Immunohistochemistry.
  • ab118061 at 1/100 dilution staining Protein Kinase A regulatory subunit I alpha in COS7 cells transiently transfected by pCMV6-ENTRY Protein Kinase A regulatory subunit I alpha by Immunofluorescence.

Anti-Protein Kinase A regulatory subunit I alpha antibody [6C7] (ab118061) 使用論文

ab118061 has not yet been referenced specifically in any publications.

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