製品の概要
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製品名Anti-Protein C antibody
Protein C 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to Protein C
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由来種Rabbit
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アプリケーション適用あり: WBmore details
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種交差性交差種: Human
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免疫原
Recombinant fragment, corresponding to a region within amino acids 145-453 of Human Protein C (NP_000303)
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ポジティブ･コントロール
- 293T, A431, H1299, HeLa, MOLT4 and Raji cell lines
法規制情報
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0 -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
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Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab97559 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 52 kDa. |
ターゲット情報
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機能Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
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組織特異性Plasma; synthesized in the liver.
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関連疾患Thrombophilia due to protein C deficiency, autosomal dominant
Thrombophilia due to protein C deficiency, autosomal recessive -
配列類似性Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻訳後修飾The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. -
細胞内局在Secreted. Golgi apparatus. Endoplasmic reticulum.
- Information by UniProt
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参照データベース
- Entrez Gene: 5624 Human
- Omim: 612283 Human
- SwissProt: P04070 Human
- Unigene: 224698 Human
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別名
- Activation peptide antibody
- Anticoagulant protein C antibody
- APC antibody
see all
画像
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Western blot - Anti-Protein C antibody (ab97559)Anti-Protein C antibody (ab97559) at 1/3000 dilution + MOLT4 whole cell lystae at 30 µg
Predicted band size: 52 kDa
10% SDS PAGE
プロトコール
参考文献
ab97559 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"