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機能
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
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組織特異性
Plasma; synthesized in the liver.
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関連疾患
Thrombophilia due to protein C deficiency, autosomal dominant
Thrombophilia due to protein C deficiency, autosomal recessive
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配列類似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain.
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翻訳後修飾
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
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細胞内局在
Secreted. Golgi apparatus. Endoplasmic reticulum.
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Information by UniProt
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参照データベース
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別名
- Activation peptide antibody
- Anticoagulant protein C antibody
- APC antibody
- Autoprothrombin IIA antibody
- Blood coagulation factor XIV antibody
- EC 3.4.21.69 antibody
- PC antibody
- proC antibody
- PROC_HUMAN antibody
- PROC1 antibody
- Protein C (inactivator of coagulation factors Va and VIIIa) antibody
- THPH3 antibody
- THPH4 antibody
- Vitamin K dependent protein C antibody
see all