Anti-Protein C 抗体 (ab97559)

製品の概要

• 製品名
  Anti-Protein C antibody
  Protein C 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Protein C
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Recombinant fragment, corresponding to a region within amino acids 145-453 of Human Protein C (NP_000303)

• ポジティブ･コントロール
  • 293T, A431, H1299, HeLa, MOLT4 and Raji cell lines

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Cardiovascular
  • Blood
  • Fibrinolysis / Thrombolysis

  • Cardiovascular
  • Blood
  • Coagulation
  • Regulatory

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa membrane extract lysate (ab29547)
  • MOLT4 whole cell lysate (ab7912)

アプリケーション

ターゲット情報

• 機能
  Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
• 組織特異性
  Plasma; synthesized in the liver.
• 関連疾患
  Thrombophilia due to protein C deficiency, autosomal dominant
  Thrombophilia due to protein C deficiency, autosomal recessive
• 配列類似性
  Belongs to the peptidase S1 family.
  Contains 2 EGF-like domains.
  Contains 1 Gla (gamma-carboxy-glutamate) domain.
  Contains 1 peptidase S1 domain.
• 翻訳後修飾
  The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
  N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
  The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
• 細胞内局在
  Secreted. Golgi apparatus. Endoplasmic reticulum.

• Target information above from: UniProt accession P04070 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 5624 Human
  • Omim: 612283 Human
  • SwissProt: P04070 Human
  • Unigene: 224698 Human
• 別名
  • Activation peptide antibody
  • Anticoagulant protein C antibody
  • APC antibody

  • Autoprothrombin IIA antibody
  • Blood coagulation factor XIV antibody
  • EC 3.4.21.69 antibody
  • PC antibody
  • proC antibody
  • PROC_HUMAN antibody
  • PROC1 antibody
  • Protein C (inactivator of coagulation factors Va and VIIIa) antibody
  • THPH3 antibody
  • THPH4 antibody
  • Vitamin K dependent protein C antibody

  see all

プロトコール

• Western blot protocols