Anti-Protective protein/Cathepsin A (PPCA) 抗体 (ab79590)

製品の概要

  • 製品名Anti-Protective protein/Cathepsin A (PPCA) antibody
    Protective protein/Cathepsin A (PPCA) 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Protective protein/Cathepsin A (PPCA)
  • 特異性Detects full length Protective protein/Cathepsin A (PPCA) and the fragment of activated Protective protein/Cathepsin A (PPCA) resulting from cleavage adjacent to Arg326.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide (Human)

  • ポジティブ・コントロール
    • Extracts from Jurkat or 293 cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 32 , 54 kDa.
ELISA 1/10000.

ターゲット情報

  • 機能Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
  • 関連疾患Defects in CTSA are the cause of galactosialidosis (GSL) [MIM:256540]. A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
  • 配列類似性Belongs to the peptidase S10 family.
  • 細胞内局在Lysosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • beta galactosidase 2 antibody
    • BETA GALACTOSIDASE PROTECTIVE PROTEIN antibody
    • beta-galactosidase 2 antibody
    • beta-galactosidase protective protein antibody
    • betagalactosidase 2 antibody
    • Carboxypeptidase C antibody
    • Carboxypeptidase L antibody
    • carboxypeptidase Y-like kininase antibody
    • Cathepsin A antibody
    • Ctsa antibody
    • deamidase antibody
    • EC 3.4.16.5 antibody
    • Glactosialidosis antibody
    • GLB2 antibody
    • Goldberg Syndrome antibody
    • GSL antibody
    • lysosomal carboxypeptidase A antibody
    • Lysosomal protective protein 20 kDa chain antibody
    • Lysosomal protective protein antibody
    • Lysosomal protective protein deficiency antibody
    • NEURAMINIDASE BETA GALACTOSIDASE EXPRESSION; NGBE antibody
    • Neuraminidase deficiency with beta-galactosidase deficiency antibody
    • NGBE antibody
    • OTTHUMP00000031778 antibody
    • OTTHUMP00000031781 antibody
    • PPCA antibody
    • PPCA deficiency antibody
    • PPGB antibody
    • PPGB_HUMAN antibody
    • Protective protein cathepsin A antibody
    • Protective protein for beta galactosidase antibody
    • Protective protein for beta-galactosidase antibody
    • Protective protein/cathepsin A deficiency antibody
    • urinary kininase antibody
    see all

Anti-Protective protein/Cathepsin A (PPCA) antibody 画像

  • All lanes : Anti-Protective protein/Cathepsin A (PPCA) antibody (ab79590) at 1/500 dilution

    Lane 1 : Extracts from Jurkat cells, treated with etoposide (25uM, 1hour)
    Lane 2 : Extracts from 293 cells, treated with etoposide (25uM, 1hour)
    Lane 3 : Extracts from 293 cells, treated with etoposide (25uM, 1hour) with Cl-peptide at 5 µg/ml

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 32 , 54 kDa

Anti-Protective protein/Cathepsin A (PPCA) antibody (ab79590) 使用論文

This product has been referenced in:
  • Lee C  et al. NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia. J Biol Chem 289:9121-35 (2014). WB ; Human . Read more (PubMed: 24550400) »

See 1 Publication for this product

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