製品の概要

  • 製品名Anti-Proteasome 26S S10 antibody
    Proteasome 26S S10 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Proteasome 26S S10
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 183-213 of Human Proteasome 26S S10 (NP_002805.1, NP_736606.1).

  • ポジティブ・コントロール
    • A549 cell line lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 24 kDa.

ターゲット情報

  • 機能Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module.
    Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
  • 組織特異性Overexpressed in hepatocellular carcinomas.
  • 配列類似性Contains 7 ANK repeats.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 26S proteasome non-ATPase regulatory subunit 10 antibody
    • 26S proteasome regulatory subunit p28 antibody
    • Ankyrin repeat protein antibody
    • dJ889N15.2 antibody
    • Gankyrin antibody
    • Hepatocellular carcinoma-associated protein p28 II antibody
    • p28 antibody
    • p28(GANK) antibody
    • Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody
    • PSD10_HUMAN antibody
    • Psmd10 antibody
    see all

Anti-Proteasome 26S S10 antibody 画像

  • Anti-Proteasome 26S S10 antibody (ab123278) at 1/100 dilution + A549 cell line lysates at 35 µg
    Developed using the ECL technique

    Predicted band size : 24 kDa

Anti-Proteasome 26S S10 antibody (ab123278) 使用論文

ab123278 has not yet been referenced specifically in any publications.

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