製品の概要

  • 製品名
    Prostratin
  • 製品の詳細
    PKC activator; reactivates HIV-1 latency
  • 生理活性の詳細
    PKC activator; reactivates HIV-1 latency (IC50 = ~0.5 µM) by PKC dependent NF-κB activation. Downregulates expression of HIV-1 receptor CD4 and its co-receptors CXCR4 and CCR5 in vitro. Non-tumor promoting.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Bedoya LM  et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol 77:965-78 (2009). Read more (PubMed: 19100719) »
  • Wender PA  et al. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320:649-52 (2008). Read more (PubMed: 18451298) »
  • Kulkosky J  et al. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98:3006-15 (2001). Read more (PubMed: 11698284) »

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