製品の概要

  • 製品名
    Prostaglandin J2
  • 製品の詳細
    Endogenous product of inflammation; PGD2 analog
  • 別名
    • PGJ2
  • 生理活性の詳細
    Endogenous highly reactive product of inflammation. PGD2 analog. Potent neurotoxin and activator of PPARα and PPARγ. Able to trigger pro-apoptotic responses in neuronal cells.
  • 精製度
    > 95%

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab80579 staining tau in SKNSH cells treated with prostaglandin J2 (ab120913), by ICC/IF. Expression of tau expression is restringed to the perinuclear zone with increased concentration of prostaglandin J2, as described in literature.
    The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120913 (prostaglandin J2) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab80579 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei (blue) were counterstained with DAPI and membrane is was stained using WGA (red).

参考文献

This product has been referenced in:
  • Arnaud LT  et al. Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. J Neurochem 110:328-42 (2009). Read more (PubMed: 19457109) »
  • Kliewer SA  et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-9 (1995). Read more (PubMed: 8521498) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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