The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC2, catalog ab3533. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
KEX2 like endoprotease 2
KEX2-like endoprotease 2
Neuroendocrine convertase 2
Prohormone convertase 2
Proprotein convertase 2
Proprotein convertase subtilisin/kexin type 2
機能Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
配列類似性Belongs to the peptidase S8 family. Furin subfamily.
細胞内局在Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
Helwig M et al. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol18:413-25 (2006).
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