製品の概要

  • 製品名
    Anti-Properdin antibody [3B10]
    Properdin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3B10] to Properdin
  • 特異性
    ab25850 recognises human properdin.
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Properdin isolated from human plasma.

  • エピトープ
    Epitope specificity differs from that of ab17780 but slightly overlap as determined by inhibition ELISA.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    3B10
  • ミエローマ
    x63-Ag8.653
  • アイソタイプ
    IgG1
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab25850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/8000. (based on use as detection antibody for antigen coated at 0.3 µg/ml).
WB Use at an assay dependent dilution. Recognises both reduced and unreduced forms of the protein.
AP Use at an assay dependent dilution. Suitable for affinity purification of human properdin after coupling to an activated CNBr-sepharose column.

ターゲット情報

  • 機能
    A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
  • 関連疾患
    Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
  • 配列類似性
    Contains 6 TSP type-1 domains.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BFD antibody
    • CFP antibody
    • Complement factor P antibody
    • Complement factor properdin antibody
    • Factor P antibody
    • PFC antibody
    • PFD antibody
    • PROP_HUMAN antibody
    • Properdin antibody
    • Properdin P factor complement antibody
    see all

プロトコール

参考文献

ab25850 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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