Anti-Prokineticin 2/PK2 抗体 (ab76747)
Key features and details
- Rabbit polyclonal to Prokineticin 2/PK2
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-Prokineticin 2/PK2 antibody
Prokineticin 2/PK2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Prokineticin 2/PK2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab76747の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/100 - 1/1000.
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特記事項 |
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IHC-P
1/100 - 1/1000. |
ターゲット情報
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機能
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. -
組織特異性
Expressed in the testis and, at low levels, in the small intestine. -
関連疾患
Defects in PROK2 are the cause of Kallmann syndrome type 4 (KAL4) [MIM:610628]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. KAL4 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip/palate, selective tooth agenesis, and bimanual synkinesis. -
配列類似性
Belongs to the AVIT (prokineticin) family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 60675 Human
- Entrez Gene: 50501 Mouse
- Entrez Gene: 192206 Rat
- Omim: 607002 Human
- SwissProt: Q9HC23 Human
- SwissProt: Q9QXU7 Mouse
- SwissProt: Q8R413 Rat
- Unigene: 528665 Human
see all -
別名
- BV8 antibody
- Bv8 homolog antibody
- MIT1 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (10)
ab76747 は 10 報の論文で使用されています。
- Schirinzi T et al. Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction. Brain Behav Immun 108:302-308 (2023). PubMed: 36549578
- Zhai J et al. Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization. Reprod Biol Endocrinol 20:76 (2022). PubMed: 35501804
- Morris EL et al. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. EMBO J 40:e108614 (2021). PubMed: 34487375
- Noda K et al. Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis. Sci Rep 11:18399 (2021). PubMed: 34526577
- Liu P et al. Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. Biosci Rep 40:N/A (2020). PubMed: 32285913
- Huang C et al. Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway. Oxid Med Cell Longev 2020:7075836 (2020). PubMed: 32922653
- Mundim MV et al. A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury. Mol Cell Neurosci 94:1-10 (2019). PubMed: 30391355
- Lattanzi R et al. Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology. Cells 8:N/A (2019). PubMed: 31766244
- Liu XQ et al. Relationship between PK2 and number of Kupffer cells during the progression of liver fibrosis in patients with HBV Turk J Med Sci 48:52-61 (2018). PubMed: 29479955
- Li Y et al. Effects of prokineticin 2 on testicular inflammation in rats. Am J Reprod Immunol 79:e12843 (2018). PubMed: 29516577