製品の概要

  • 製品名Anti-PRODH antibody
    PRODH 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to PRODH
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    ERDGSGTNKRDKQYQ

    with a cysteine residue linker, corresponding to internal sequence amino acids 168 - 182 of Human PRODH (O43272)

  • ポジティブ・コントロール
    • Human brain cerebellum, colon and liver tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Converts proline to delta-1-pyrroline-5-carboxylate.
  • 組織特異性Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • パスウェイAmino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • 関連疾患Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 配列類似性Belongs to the proline oxidase family.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HSPOX2 antibody
    • mitochondrial antibody
    • P53 induced gene 6 protein antibody
    • p53-induced gene 6 protein antibody
    • PIG6 antibody
    • POX antibody
    • PROD_HUMAN antibody
    • PRODH 1 antibody
    • PRODH 2 antibody
    • PRODH antibody
    • PRODH1 antibody
    • PRODH2 antibody
    • Proline dehydrogenase antibody
    • proline dehydrogenase (oxidase) 1 antibody
    • proline dehydrogenase (proline oxidase) antibody
    • Proline dehydrogenase 1 antibody
    • Proline dehydrogenase 1, mitochondrial antibody
    • Proline oxidase 1 antibody
    • Proline oxidase 2 antibody
    • Proline oxidase antibody
    • Proline oxidase, mitochondrial antibody
    • Proline oxidase, mitochondrial precursor antibody
    • SCZD4 antibody
    • TP53I6 antibody
    • tumor protein p53 inducible protein 6 antibody
    see all

Anti-PRODH antibody 画像

  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human brain cerebellum by Immunohistochemistry.
  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human colon tissue by Immunohistochemistry.
  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-PRODH antibody (ab113958) 使用論文

ab113958 has not yet been referenced specifically in any publications.

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