製品の概要

  • 製品名
    Procainamide hydrochloride
  • 製品の詳細
    Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor.
  • 生理活性の詳細
    Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Lee BH  et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem 280:40749-56 (2005). Read more (PubMed: 16230360) »
  • Reinker S  et al. Effects of procainamide on membrane properties of thalamic neurons. Proc West Pharmacol Soc 44:89-92 (2001). Read more (PubMed: 11794008) »
  • Ellenbogen KA  et al. Procainamide: a perspective on its value and danger. Heart Dis Stroke 2:473-6 (1993). Read more (PubMed: 8137053) »
  • Zamponi GW  et al. Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation. Biophys J 65:2324-34 (1993). Read more (PubMed: 8312472) »

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