Anti-Probable hydrolase PNKD 抗体 (ab112936)

製品の概要

  • 製品名Anti-Probable hydrolase PNKD antibody
    Probable hydrolase PNKD 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Probable hydrolase PNKD
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 41-70 of Human Probable hydrolase PNKD (NP_001070867.1, NP_072094.1, NP_056303.3).

  • ポジティブ・コントロール
    • Mouse liver tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab112936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

ターゲット情報

  • 機能Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
  • 組織特異性Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.
  • 関連疾患Defects in PNKD are the cause of dystonia type 8 (DYT8) [MIM:118800]. DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face.
  • 配列類似性Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • 翻訳後修飾Isoform 2 is phosphorylated at Ser-121 upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus; Mitochondrion and Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2210013N15Rik antibody
    • 2810403H05Rik antibody
    • AI854243 antibody
    • BRAIN PROTEIN 17 antibody
    • BRP17 antibody
    • DYT8 antibody
    • FKSG19 antibody
    • FPD1 antibody
    • KIAA1184 antibody
    • KIPP1184 antibody
    • MNCb-5687 antibody
    • MR-1 antibody
    • MR1 antibody
    • Myofibrillogenesis regulator 1 antibody
    • Paroxysmal nonkinesiogenic dyskinesia protein antibody
    • PDC antibody
    • PKND1 antibody
    • Pnkd antibody
    • PNKD_HUMAN antibody
    • Probable hydrolase PNKD antibody
    • TAHCCP2 antibody
    • Trans-activated by hepatitis C virus core protein 2 antibody
    see all

Anti-Probable hydrolase PNKD antibody 画像

  • Anti-Probable hydrolase PNKD antibody (ab112936) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 43 kDa

Anti-Probable hydrolase PNKD antibody (ab112936) 使用論文

ab112936 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step 8% goat serum/0.3%BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 0.3% · Temperature: 25°C
Antigen retrieval step None
Sample Mouse Tissue sections (brain)
Specification brain
Permeabilization Yes - 0.33% Triton X-100
Fixative Paraformaldehyde
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投稿 Aug 28 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"