製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to proANP
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Sheep, Cow, Dog, Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide within Human proANP aa 50-150 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P01160
    (Peptide available as ab106205)

  • ポジティブ・コントロール
    • This antibody gave a positive signl in human heart, formalin-fixed, paraffin-embedded, tissue section.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab105450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 関連疾患
    Atrial standstill 2
    Atrial fibrillation, familial, 6
  • 配列類似性
    Belongs to the natriuretic peptide family.
  • 翻訳後修飾
    Cleaved by CORIN upon secretion to produce the functional hormone.
    Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ANF antibody
    • ANF_HUMAN antibody
    • ANP antibody
    • ATFB6 antibody
    • Atrial natriuretic factor antibody
    • Atrial natriuretic peptide antibody
    • Atriopeptin antibody
    • ATRST2 antibody
    • Cardiodilatin antibody
    • Cardiodilatin-related peptide antibody
    • Cardionatrin antibody
    • CDD ANF antibody
    • CDD antibody
    • CDD-ANF antibody
    • CDP antibody
    • Natriuretic peptide A antibody
    • Natriuretic peptide precursor A antibody
    • Natriuretic peptides A antibody
    • NPPA antibody
    • PND antibody
    • Prepronatriodilatin antibody
    • Pronatriodilatin antibody
    see all

画像

  • IHC image of pro ANP staining in human heart formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab105450, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

プロトコール

参考文献

ab105450 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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