製品の概要

  • 製品名
    Pro-myristic acid
  • 製品の詳細
    Negative control for MiTMAB™ and OcTMAB™
  • 生理活性の詳細
    Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an in vitro inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 μM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.
  • 特記事項
    Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd.

製品の特性

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参考文献

This product has been referenced in:
  • Quan A  et al. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol Pharmacol 72:1425-39 (2007). Read more (PubMed: 17702890) »

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