製品の概要

  • 製品名Anti-pro Caspase 7 antibody [Y33]
  • 製品の詳細
    Rabbit monoclonal [Y33] to pro Caspase 7
  • 特異性The antibody only recognizes the pro-form of Caspase-7. It does not react with the cleaved forms (active enzyme) of Caspase-7.
  • アプリケーション適用あり: WB, IHC-P, ICC/IFmore details
    適用なし: Flow Cyt or IP
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to N-terminal residues of human Pro-Caspase-7.

  • ポジティブ・コントロール
    • Jurkat cell lysate and human lung squamous carcinoma.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab32067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
ICC/IF
  • 追加情報ICC/IF: 1/50.
    IHC-P: 1/50.

    WB: 1/1000. Detects a band of approximately 34 kDa (predicted molecular weight: 34 kDa).

    Is unsuitable for FACS or IP.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-
      -Gly-217' bond. Overexpression promotes programmed cell death.
    • 組織特異性Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
    • 配列類似性Belongs to the peptidase C14A family.
    • 翻訳後修飾Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • apoptosis-related cysteine peptidase antibody
      • Apoptotic protease Mch-3 antibody
      • CASP-7 antibody
      • CASP7 antibody
      • CASP7_HUMAN antibody
      • Caspase-7 subunit p11 antibody
      • CMH-1 antibody
      • ICE-LAP3 antibody
      • ICE-like apoptotic protease 3 antibody
      see all

    Anti-pro Caspase 7 antibody [Y33] 画像

    • Anti-pro Caspase 7 antibody [Y33] (ab32067) at 1/1000 dilution + Jurkat cell lysate

      Predicted band size : 34 kDa
      Observed band size : 34 kDa
    • Immunohistochemical analysis of paraffin-embedded human lung squamous carcinoma using ab32067 at 1/50 dilution.

    Anti-pro Caspase 7 antibody [Y33] (ab32067) 使用論文

    ab32067 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"