製品の概要

  • 製品名
    Anti-pro Caspase-12 antibody
    pro Caspase-12 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to pro Caspase-12
  • 特異性
    The antibody only recognizes the prodomain, not the activated form.
  • アプリケーション
    適用あり: IHC-P, ICC/IF, ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Mouse pro Caspase-12 aa 100-116.
    Sequence:

    CTPSSPSESKRKVEDDE


    Database link: Q6UXS9
    (Peptide available as ab8374)

  • ポジティブ・コントロール
    • Mouse brain tissue lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C. Do Not Freeze.
  • バッファー
    PBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度
    IgG fraction
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab8117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
ELISA Use at an assay dependent concentration.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa.Can be blocked with Mouse Caspase-12 peptide (ab8374).

ターゲット情報

  • 関連性
    Caspase 12 is activated by ER stress, including disruption of ER calcium homeostasis and mediates ER stress-induced apoptosis. Caspase 12 is co-localized to the ER with several proteins that are involved in Alzheimers disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase 12 mediates cytotoxicity induced by amyloid-beta. It is ubiquitously expressed in mouse tissue.
  • 細胞内局在
    Endoplasmic reticulum
  • 参照データベース
  • 別名
    • CASP12 antibody
    • CASP12P1 antibody

Anti-pro Caspase-12 antibody 画像

  • All lanes : Anti-pro Caspase-12 antibody (ab8117) at 1 µg/ml

    Lane 1 : Murine brain tissue lysate with absence of blocking peptide
    Lane 2 : Murine brain tissue lysate with presence of blocking peptide
  • ab8117 staining Caspase-12 in mouse liver tissue by IHC

  • Immunofluorescence of Caspase-12 in Mouse Liver cells using ab8117 at 10 ug/ml.

Anti-pro Caspase-12 antibody (ab8117) 使用論文

This product has been referenced in:
  • Fatma N  et al. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol 301:C954-67 (2011). Read more (PubMed: 21677259) »

See 1 Publication for this product

Product Wall

We do not have an Italian distributor but you can place your orders directly through us. This can be done online, by fax (0033 1223 472038), phone (0033 1223 472030) or email (orders@abcam.com). Ab8117 does cross-react with human. Unfortunately I ...

Read More

Thank you very much for your enquiry. For both ab8117 and ab10455, the band should be at about 50-55 kDa. If you have any further questions, please contact us again.

This antibody recognizes the uncleaved (whole) form of the caspase only.

This antibody recognizes the uncleaved (whole) form of the caspase only.

No, I'm afraid that we do not have an blot image for this antibody. All the information we have is on the datasheet.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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