製品の概要

  • 製品名Anti-PRMT7 antibody
    PRMT7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PRMT7
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Horse, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 380-429 (GEINDQDRTD HYAQALRTVL LPGSVCLCVS DGSLLSMLAH HLGAEQVFTV) of Mouse PRMT7 (NP_663379).

  • ポジティブ・コントロール
    • Mouse Thymus lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab116258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 78 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
  • 関連疾患Defects in PRMT7 are associated with mild intellectual disabilityy, obesity and symmetrical shortening of the digits and posterior metacarpals and metatarsals. The phenotype is a phenocopy of pseudohypoparathyroidism (PHP).
  • 配列類似性Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
    Contains 2 SAM-dependent MTase PRMT-type domains.
  • 細胞内局在Cytoplasm, cytosol. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • [Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody
    • ANM7_HUMAN antibody
    • FLJ10640 antibody
    • Histone-arginine N-methyltransferase PRMT7 antibody
    • KIAA1933 antibody
    • Myelin basic protein arginine N methyltransferase antibody
    • OTTHUMP00000174863 antibody
    • PRMT7 antibody
    • Protein arginine methyltransferase 7 antibody
    • Protein arginine N-methyltransferase 7 antibody
    see all

Anti-PRMT7 antibody 画像

  • Anti-PRMT7 antibody (ab116258) at 1 µg/ml + Mouse Thymus lysate at 10 µg

    Predicted band size : 78 kDa

Anti-PRMT7 antibody (ab116258) 使用論文

ab116258 has not yet been referenced specifically in any publications.

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