製品の概要

  • 製品名Anti-Presenilin 2 antibody
    Presenilin 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Presenilin 2
  • 特異性ab106351 does not cross react with other proteins.
  • アプリケーション適用あり: WB, IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Cow, Pig
  • 免疫原

    Synthetic peptide corresponding to Human Presenilin 2 aa 319-334 (internal sequence).
    Sequence:

    YDPEMEEDSYDSFGEP


    Database link: P49810

  • ポジティブ・コントロール
    • Rat brain tissue lysate; MCF7, HeLa, SMMC, CEM whole cell lysates; Rat brain tissue.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 1 µg/ml.

ターゲット情報

  • 機能Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
  • 組織特異性Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
  • 関連疾患Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 配列類似性Belongs to the peptidase A22A family.
  • ドメインThe PAL motif is required for normal active site conformation.
  • 翻訳後修飾Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
    Phosphorylated on serine residues.
  • 細胞内局在Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AD3L antibody
    • AD3LP antibody
    • AD4 antibody
    • AD5 antibody
    • Alzheimer disease 4 antibody
    • CMD1V antibody
    • E5-1 antibody
    • OTTHUMP00000035671 antibody
    • OTTHUMP00000035672 antibody
    • OTTHUMP00000228286 antibody
    • OTTHUMP00000228288 antibody
    • Presenilin 2 (Alzheimer disease 4) antibody
    • Presenilin 2 antibody
    • Presenilin-2 CTF subunit antibody
    • PS-2 antibody
    • PS2 antibody
    • Psen2 antibody
    • PSN2_HUMAN antibody
    • PSNL2 antibody
    • STM-2 antibody
    • STM2 antibody
    see all

Anti-Presenilin 2 antibody 画像

  • Immunohistochemical analysis of paraffin-embedded Rat Kidney tissue labeling Presenilin 2 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Rat Cardiac Muscle tissue labeling Presenilin 2 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Human Mammary Cancer tissue labeling Presenilin 2 with ab106351.

  • All lanes : Anti-Presenilin 2 antibody (ab106351) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : SMMC whole cell lysate
    Lane 6 : CEM whole cell lysate


    Predicted band size : 50 kDa
  • ab106351, at 1µg/ml, staining Presenilin 2 in frozen Rat brain tissue sections by Immunohistochemistry.

Anti-Presenilin 2 antibody (ab106351) 使用論文

ab106351 has not yet been referenced specifically in any publications.

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