製品の概要

  • 製品名Anti-PRDM16 antibody
    PRDM16 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PRDM16
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1250 to the C-terminus of Human PRDM16 .

    (Peptide available as ab95842.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following whole cell lysates: HeLa; Jurkat; HEK293.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab85874 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 140 kDa).

ターゲット情報

  • 機能Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
  • 組織特異性Expressed in uterus and kidney.
  • 関連疾患Note=A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia.
  • 配列類似性Contains 10 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CMD1LL antibody
    • KIAA1675 antibody
    • LVNC8 antibody
    • MDS1/EVI1 like gene 1 antibody
    • MDS1/EVI1-like gene 1 antibody
    • MEL1 antibody
    • PFM 13 antibody
    • PFM13 antibody
    • PR domain containing 16 antibody
    • PR domain containing protein 16 antibody
    • PR domain zinc finger protein 16 antibody
    • PR domain-containing protein 16 antibody
    • PRD16_HUMAN antibody
    • Prdm16 antibody
    • Transcription factor MEL 1 antibody
    • Transcription factor MEL1 antibody
    see all

Anti-PRDM16 antibody 画像

  • All lanes : Anti-PRDM16 antibody (ab85874) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate
    Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg/ml per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 140 kDa
    Observed band size : 150 kDa (why is the actual band size different from the predicted?)


    Exposure time : 12 minutes

Anti-PRDM16 antibody (ab85874) 使用論文

ab85874 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"