Anti-PR3 抗体 [WGM2] (ab91181)
Key features and details
- Mouse monoclonal [WGM2] to PR3
- Suitable for: Inhibition Assay, ELISA, IHC-Fr, IHC-P, Flow Cyt, WB, Functional Studies
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-PR3 antibody [WGM2]
PR3 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [WGM2] to PR3 -
由来種
Mouse -
アプリケーション
適用あり: Inhibition Assay, ELISA, IHC-Fr, IHC-P, Flow Cyt, WB, Functional Studiesmore details -
種交差性
交差種: Human -
免疫原
Full length protein. This information is proprietary to Abcam and/or its suppliers.
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特記事項
ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
0.2 µm filtered antibody solution -
一次抗体 備考
ab91181 blocks the PR3 activity and partially inhibits the binding of Human PR3-ANCA to PR3; it can be used in immuno assays, for inhibition of biological PR3 activity and induction of monocytes and neutrophils activation. -
ポリ/モノ
モノクローナル -
クローン名
WGM2 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab91181の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Inhibition Assay |
Use at an assay dependent concentration.
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ELISA |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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WB |
Use at an assay dependent concentration.
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Inhibition Assay
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. |
ターゲット情報
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機能
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. -
配列類似性
Belongs to the peptidase S1 family. Elastase subfamily.
Contains 1 peptidase S1 domain. - Information by UniProt
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参照データベース
- Entrez Gene: 5657 Human
- Omim: 177020 Human
- SwissProt: P24158 Human
- Unigene: 928 Human
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別名
- ACPA antibody
- AGP 7 antibody
- AGP7 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (13)
ab91181 は 13 報の論文で使用されています。
- Jiang ZZ et al. Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells. Oncoimmunology 11:2052418 (2022). PubMed: 35309732
- Hao J et al. Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils. BMC Immunol 20:22 (2019). PubMed: 31248381
- Kasperkiewicz P et al. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils. J Am Chem Soc 139:10115-10125 (2017). PubMed: 28672107
- Singh N et al. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech 9:885-97 (2016). Human . PubMed: 27483354
- Murakami M et al. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS One 9:e110677 (2014). PubMed: 25330301