製品の概要

  • 製品名Anti-PQBP1 antibody
    PQBP1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to PQBP1
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human
  • 免疫原

    Recombinant fragment: LAPYPKSKKA VSRKDEELDP MDPSSYSDAP RGTWSTGLPK RNEAKTGADT, corresponding to amino acids 184-265 of human PQBP1 (NP_005701) with a 26 kDa tag.

  • ポジティブ・コントロール
    • Immunogen

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.

    WB: 1/500 - 1/1000. Predicted molecular weight: 30 kDa.
    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

  • ターゲット情報

    • 機能May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.
    • 組織特異性Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.
    • 関連疾患Defects in PQBP1 are the cause of Renpenning syndrome 1 (RENS1) [MIM:309500]; also known as Sutherland-Haan X-linked mental retardation syndrome (SHS) or X-linked mental retardation syndromes MRXS3/MRXS8/MRX55. The clinical features are mental retardation, microcephaly, short stature, and small testes. The craniofacies tends to be narrow and tall with upslanting palpebral fissures, abnormal nasal configuration, cupped ears, and short philtrum. The nose may appear long or bulbous, with overhanging columella. Less consistent manifestations include ocular colobomas, cardiac malformations, cleft palate, and anal anomalies. RENS1 is more frequently in males than in females where little or no expression is found.
    • 配列類似性Contains 1 WW domain.
    • ドメインThe WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with C-terminal domain of RNA polymerase II large subunit.
    • 細胞内局在Nucleus. Co-localized with POU3F2. Co-localized with ATXN1 in nuclear inclusion bodies.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 38 kDa nuclear protein containing a WW domain antibody
      • Mental retardation, X linked 55 antibody
      • MRX55 antibody
      • MRXS3 antibody
      • MRXS8 antibody
      • Npw38 antibody
      • Nuclear protein containing WW domain 38 kD antibody
      • OTTHUMP00000025808 antibody
      • Polyglutamine binding protein 1 antibody
      • Polyglutamine tract binding protein 1 antibody
      • Polyglutamine tract-binding protein 1 antibody
      • Polyglutamine-binding protein 1 antibody
      • PQBP 1 antibody
      • PQBP-1 antibody
      • PQBP1 antibody
      • PQBP1_HUMAN antibody
      • RENS1 antibody
      • SHS antibody
      • Sutherland Haan X linked mental retardation syndrome antibody
      see all

    Anti-PQBP1 antibody 画像

    • Anti-PQBP1 antibody (ab77041) at 1/500 dilution + immunogen at 0.2 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

      Predicted band size : 30 kDa
      Observed band size : 35 kDa (why is the actual band size different from the predicted?)

    Anti-PQBP1 antibody (ab77041) 使用論文

    ab77041 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab77041.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"