製品の概要

  • 製品名Anti-PPP4C antibody
    PPP4C 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PPP4C
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1 and 50 of Human PPP4C (NP_002711.1)

  • ポジティブ・コントロール
    • Human controls: metastatic lymph node carcinoma. Breast Carcinoma, Colon Carcinoma, Laryngeal Squamous Cell Carcinoma, Linitis Plastica Stomach Cancer,Metastatic Lymph Node, Non-Small Cell Lung Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor,Prostate Carcinoma, Skin Basal Cell Carcinoma, Small Cell Lung Cancer, Stomach Adenocarcinoma,Testicular Seminoma.
      Mouse Controls: Squamous Cell Carcinoma

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
    • 配列類似性Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
    • 細胞内局在Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • PP X antibody
      • PP-X antibody
      • Pp4 antibody
      • PP4C antibody
      • PP4C_HUMAN antibody
      • PPH3 antibody
      • PPP4 antibody
      • ppp4c antibody
      • PPX antibody
      • protein phosphatase 4 (formerly X), catalytic subunit antibody
      • Protein phosphatase 4 catalytic subunit antibody
      • Protein phosphatase X antibody
      • protein phosphatase X, catalytic subunit antibody
      • Serine/threonine protein phosphatase 4 catalytic subunit antibody
      • Serine/threonine-protein phosphatase 4 catalytic subunit antibody
      see all

    Anti-PPP4C antibody 画像

    • Detection of Human PPP4C by Immunohistochemistry.
      Sample: FFPE section of Human metastatic lymph node.
      Antibody: ab84396 used at a dilution of 1/500.
      Detection: DAB.
    • Detection of Mouse PPP4C by Immunohistochemistry.
      Sample: FFPE section of Mouse squamous cell carcinoma.
      Antibody: ab84396 used at a dilution of 1/100.
      Detection: DAB staining.

    Anti-PPP4C antibody (ab84396) 使用論文

    ab84396 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84396.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"