Anti-PPP2R4 抗体 (ab87673)

製品の概要

• 製品名
  Anti-PPP2R4 antibody
  PPP2R4 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to PPP2R4
• 特異性
  This antibody is expected to recognize all reported isoforms (NP_821068.1; NP_066954.2; NP_821070.1).
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Mouse, Rat, Human
  交差が予測される動物種: Rabbit, Cow, Dog, Orangutan
• 免疫原

  Synthetic peptide:

  C-GSLLPIHPVTSG

  , corresponding to C terminal amino acids 312-323 of Human PPP2R4 (NP_066954.2).

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human, mouse or rat Liver lysate and HepG2 cell lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris saline, pH 7.3
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab87673 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Phosphatases

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能
  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
• 組織特異性
  Widely expressed.
• 配列類似性
  Belongs to the PTPA-type PPIase family.
• 細胞内局在
  Cytoplasm. Nucleus.

• Target information above from: UniProt accession Q15257 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 5524 Human
  • Entrez Gene: 110854 Mouse
  • Entrez Gene: 362102 Rat
  • Omim: 600756 Human
  • SwissProt: Q15257 Human
  • SwissProt: P58389 Mouse
  • Unigene: 400740 Human
  • Unigene: 275393 Mouse
• 別名
  • subunit B'' antibody
  • KIAA0044 antibody
  • MGC2184 antibody

  • Phosphotyrosyl phosphatase activator antibody
  • PP2A antibody
  • PP2A phosphatase activator antibody
  • PP2A subunit B' antibody
  • PP2A subunit B' isoform PR53 antibody
  • PP2A subunit B' PR53 isoform antibody
  • PPP2R4 antibody
  • PR53 antibody
  • PR53 isoform antibody
  • Protein phosphatase 2, regulatory subunit B-prime antibody
  • Protein phosphatase 2A activator regulatory subunit 4 antibody
  • Protein phosphatase 2A regulatory subunit B' (PR 53) antibody
  • PTPA antibody
  • PTPA_HUMAN antibody
  • Serine/threonine protein phosphatase 2A regulatory subunit B' antibody
  • Serine/threonine-protein phosphatase 2A activator antibody
  • Serine/threonine-protein phosphatase 2A regulatory subunit 4 antibody
  • Serine/threonine-protein phosphatase 2A regulatory subunit B'' antibody

  see all

プロトコール

• Western blot protocols