製品の概要

  • 製品名Anti-PPP2R2B antibody
    PPP2R2B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PPP2R2B
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the center region of Human PPP2R2B (NP_004567.1).

  • ポジティブ・コントロール
    • Hela cell line lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab93131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 52 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
    • 組織特異性Brain.
    • 関連疾患Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).
    • 配列類似性Belongs to the phosphatase 2A regulatory subunit B family.
      Contains 7 WD repeats.
    • ドメインThe N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity.
      The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Membrane and Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 2ABB_HUMAN antibody
      • B55 beta antibody
      • Beta isoform of regulatory subunit B55 protein phosphatase 2 antibody
      • MGC24888 antibody
      • PP2A B55beta antibody
      • PP2A PR55B antibody
      • PP2A subunit B B beta isoform antibody
      • PP2A subunit B B55 beta isoform antibody
      • PP2A subunit B isoform B55 beta antibody
      • PP2A subunit B isoform B55-beta antibody
      • PP2A subunit B isoform beta antibody
      • PP2A subunit B isoform PR55 beta antibody
      • PP2A subunit B isoform PR55-beta antibody
      • PP2A subunit B isoform R2 beta antibody
      • PP2A subunit B isoform R2-beta antibody
      • PP2A subunit B PR55 beta isoform antibody
      • PP2A subunit B R2 beta isoform antibody
      • Ppp2r2b antibody
      • PR2AB beta antibody
      • PR2AB55 beta antibody
      • PR2APR55 beta antibody
      • PR52B antibody
      • PR55 beta antibody
      • Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform antibody
      • Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform antibody
      • Protein phosphatase 2 regulatory subunit B antibody
      • Protein phosphatase 2 regulatory subunit B beta isoform antibody
      • SCA 12 antibody
      • SCA12 antibody
      • Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
      • Serine/threonine protein phosphatase 2A neuronal isoform antibody
      • Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
      see all

    Anti-PPP2R2B antibody 画像

    • Anti-PPP2R2B antibody (ab93131) at 1/100 dilution + Hela cell line lysate at 35 µg

      Predicted band size : 52 kDa

    Anti-PPP2R2B antibody (ab93131) 使用論文

    ab93131 has not yet been referenced specifically in any publications.

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