製品の概要

  • 製品名Anti-PPOX antibody
    PPOX 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to PPOX
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: EASGCVLSQE LFQQRAQEAA ATQLGLKEMP SHCLVHLHKN CIPQYTLGHW QKLESARQFL TAHRLPLTLA GASYEGVAVN DCIESGRQAA VSVLGTEPNS , corresponding to amino acids 378-478 of Human PPOX

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
    • 組織特異性Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • パスウェイPorphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
    • 関連疾患Defects in PPOX are the cause of variegate porphyria (VP) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. PV is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease.
    • 配列類似性Belongs to the protoporphyrinogen oxidase family.
    • 細胞内局在Mitochondrion inner membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • MGC8485 antibody
      • PPO antibody
      • PPOX antibody
      • PPOX_HUMAN antibody
      • Protoporphyrinogen oxidase antibody
      • V290M antibody
      • Variegate porphyria antibody
      • VP antibody
      see all

    Anti-PPOX antibody 画像

    • PPOX antibody (ab58147) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lung, adenosqumous cell carcinoma.
    • Western blot against tagged recombinant protein immunogen using ab58147 PPOX antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-PPOX antibody (ab58147) 使用論文

    ab58147 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab58147.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"