製品の概要

  • 製品名PPADS
  • 製品の詳細
    P2 purinergic receptor antagonist
  • 生理活性の詳細P2 purinergic receptor antagonist.

製品の特性

    PPADS 画像

    • Astrocyte Ca2+ signal inhibition does not affect interictal discharges. (A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (ab120008) (n=7), PPADS (ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.
    • Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (ab120008) and PPADS (ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.

    PPADS (ab120009) 使用論文

    This product has been referenced in:
    • Lin Y  et al. P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity. Neurosci Lett 377:97-100 (2005). Read more (PubMed: 15740844) »
    • von Kügelgen I & Wetter A Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch Pharmacol 362:310-23 (2000). Read more (PubMed: 11111826) »
    • Lambrecht G Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedebergs Arch Pharmacol 362:340-50 (2000). Read more (PubMed: 11111828) »

    See all 4 Publications for this product

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    J’ai informé abcamBiochemicals pour voir si on pourrait ajouter une note sur la fiche technique comme quoi il faut vérifier le CoA des biochemicals avant l’achat d’un lot pour savoir le poids moléculaire exact.
    La prochaine fois que vous comm...

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    Pour ce genre de produit, le poids moléculaire va changer de lot à lot dû au niveau d’hydration. Pour tous nos « Biochemicals » nous avons donc téléchargés le certificat d’analyse (CoA)) de chaque lot sur notre site web.


    J’ai contacté le laboratoire qui m’a confirmé que pour le lot que vous avez reçu, le poids moléculaire est bien 743.42. Ceci est parce que la molécule est hydratée et contient 8 molécules d’eau, donc la formule devient C14H10N3Na4O12PS2.8H2O.

    Please find the CoA attached.

    I hope this is helpful. Please contact me again if you have any further questions.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"