製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PP2A beta
  • 特異性
    ab32673 recognises PP2A beta. Does not crossreact with PP1 or other protein phosphatases.
  • アプリケーション
    適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse, Rat, Rabbit, Human
    交差が予測される動物種: Chicken, Cow, Dog, Xenopus laevis, Caenorhabditis elegans, Drosophila melanogaster, Zebrafish, Cynomolgus monkey, Dictyostelium discoideum
  • 免疫原

    Synthetic peptide corresponding to Human PP2A beta aa 296-309 (C terminal) conjugated to keyhole limpet haemocyanin.
    Sequence:

    GEPHVTRRTPDYFL

  • ポジティブ・コントロール
    • Rabbit brain membrane cytosol and human A431 RIPA cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab32673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 35 kDa.
IP Use a concentration of 4 - 5 µg/ml.

ターゲット情報

  • 機能
    PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
  • 配列類似性
    Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 翻訳後修飾
    Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).
    Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • 細胞内局在
    Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • PP2A beta antibody
    • PP2A-beta antibody
    • PP2AB_HUMAN antibody
    • PP2Abeta antibody
    • PP2CB antibody
    • Ppp2cb antibody
    • Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform antibody
    • Protein phosphatase 2 catalytic subunit beta isozyme antibody
    • Protein phosphatase 2, catalytic subunit, beta isoform antibody
    • Protein phosphatase 2A catalytic subunit beta isoform antibody
    • Protein phosphatase type 2A catalytic subunit antibody
    • Serine/threonine protein phosphatase 2A catalytic subunit beta antibody
    • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform antibody
    see all

参考文献

ab32673 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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