製品の概要

  • 製品名Anti-PP1C gamma antibody
    PP1C gamma 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to PP1C gamma
  • 特異性No cross reactivity with other recombinant pp1 isoforms.
  • アプリケーション適用あり: IP, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    TPPRGMITKQAKK

    conjugated to KLH, corresponding to amino acids 311-323 of Human PPP1G1.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab16387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent concentration.
WB 1/500 - 1/1000. Predicted molecular weight: 37 kDa.

ターゲット情報

  • 機能Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
  • 配列類似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 細胞内局在Cytoplasm. Nucleus. Nucleus > nucleolus. Nucleus > nucleoplasm. Nucleus speckle. Chromosome > centromere > kinetochore. Cleavage furrow. Midbody. Colocalizes with SPZ1 in the nucleus (By similarity). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • PP 1G antibody
    • PP-1G antibody
    • PP1C antibody
    • PP1G antibody
    • PP1G_HUMAN antibody
    • PP1gamma antibody
    • PPP 1G antibody
    • PPP1CC antibody
    • PPP1G antibody
    • Protein phosphatase 1, catalytic subunit, gamma isozyme antibody
    • Protein phosphatase 1C catalytic subunit antibody
    • Serine/threonine phosphatase 1 gamma antibody
    • Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody
    • Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody
    see all

Anti-PP1C gamma antibody (ab16387) 使用論文

This product has been referenced in:
  • Seiki T  et al. HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1? in cervical malignancy. BMC Cancer 15:230 (2015). Read more (PubMed: 25886518) »
  • Kernohan KD  et al. Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability. Hum Mol Genet 24:6293-300 (2015). WB, IP ; Human . Read more (PubMed: 26307080) »

See all 4 Publications for this product

Product Wall

This antibody is to the gamma subunit or isoform of the protein phosphatase 1 protein. If this does not help, then please let us know and we'll further investigate.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"