製品の概要

  • 製品名Anti-POT1 antibody
    POT1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to POT1
  • 特異性ab67298 recognizes human POT1 variant 3.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Dog, Chimpanzee, Cynomolgus Monkey, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    MSLVPATNYIYTPLNQ

    conjugated to KLH, corresponding to N terminal amino acids 1-16 of Human POT1

  • ポジティブ・コントロール
    • A lysate of C2 or HeLa Nuclear extract.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 精製度Ion Exchange Chromatography
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab67298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: 1/1000 - 1/2000. Detects a band of approximately 55-58 kDa (predicted molecular weight for variant 3: ~60 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.
    • 組織特異性Ubiquitous.
    • 配列類似性Belongs to the telombin family.
    • 細胞内局在Nucleus. Chromosome > telomere. Colocalizes with telomeric DNA.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DKFZP586D211 antibody
      • hPot 1 antibody
      • hPot1 antibody
      • POT 1 antibody
      • POT1 antibody
      • POT1 like telomere end-binding protein antibody
      • POT1 protection of telomeres 1 homolog antibody
      • POT1-like telomere end-binding protein antibody
      • POTE1_HUMAN antibody
      • Protection of telomeres 1 antibody
      • Protection of telomeres 1 homolog (S. pombe) antibody
      • Protection of telomeres protein 1 antibody
      see all

    Anti-POT1 antibody (ab67298) 使用論文

    ab67298 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67298.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"