製品の概要

  • 製品名Anti-PON1 antibody
    PON1 一次抗体 製品一覧
  • 製品の詳細
    Chicken polyclonal to PON1
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Fusion protein: MYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIV, corresponding to amino acids 125-170 of PON1

  • ポジティブ・コントロール
    • AEC staining method: Oral cancer epithelium

アプリケーション

Our Abpromise guarantee covers the use of ab26930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/200.

ターゲット情報

  • 機能Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
  • 組織特異性Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
  • 関連疾患Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
  • 配列類似性Belongs to the paraoxonase family.
  • 翻訳後修飾Glycosylated.
    The signal sequence is not cleaved.
    Present in two forms, form B contains a disulfide bond, form A does not.
  • 細胞内局在Secreted > extracellular space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A esterase 1 antibody
    • A-esterase 1 antibody
    • Aromatic esterase 1 antibody
    • Arylesterase 1 antibody
    • Arylesterase B type antibody
    • ESA antibody
    • Esterase A antibody
    • K 45 antibody
    • K-45 antibody
    • MVCD5 antibody
    • Paraoxonase 1 antibody
    • Paraoxonase antibody
    • Paraoxonase B type antibody
    • Paraoxonase, plasma antibody
    • Paraoxonase1 antibody
    • PON 1 antibody
    • PON antibody
    • PON1 antibody
    • PON1_HUMAN antibody
    • Serum aryldiakylphosphatase antibody
    • Serum aryldialkylphosphatase 1 antibody
    • Serum paraoxonase/arylesterase 1 antibody
    see all

Anti-PON1 antibody 画像

  • Anti-PON1 antibody (ab26930) at 1/3000 dilution + E. coli derived protein

    Secondary
    Goat anti IgY HRP at 1/10000 dilution
    Developed using the ECL technique

    Predicted band size : 40 kDa
    Observed band size : 17 kDa (why is the actual band size different from the predicted?)

Anti-PON1 antibody (ab26930) 使用論文

ab26930 has not yet been referenced specifically in any publications.

Product Wall

Sorry for the long wait. I have another update about one of the products you previously enquired. ab26930: We have not tested this product for cross reactivity with PON2 and PON3. ab24261: There is no reply from the originator and I would as...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"