Anti-POLR3B 抗体 (ab114967)

製品の概要

• 製品名Anti-POLR3B antibody
  POLR3B 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to POLR3B
• アプリケーション適用あり: IHC-Pmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus, Elephant
• 免疫原

  Synthetic peptide, corresponding to a region within amino acids 1083-1133 of Human POLR3B (NP_060552.3).

• ポジティブ･コントロール
  • Human Breast Carcinoma, Hodgkins Lymphoma and Testicular Seminoma tissues.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: 0.09% Sodium azide
  Constituents: 99% Tris buffered saline, 0.1% BSA
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol III Transcription

  • Epigenetics and Nuclear Signaling
  • Transcription
  • RNA polymerase

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Testis tumor (human): seminoma tissue slides (ab5129)

アプリケーション

ターゲット情報

• 機能DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
• 配列類似性Belongs to the RNA polymerase beta chain family.
• 細胞内局在Nucleus.

• Target information above from: UniProt accession Q9NW08 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 55703 Human
  • SwissProt: Q9NW08 Human
  • Unigene: 610795 Human
  • Unigene: 62696 Human
• 別名
  • C128 antibody
  • DNA directed RNA polymerase III 127.6 kDa polypeptide antibody
  • DNA directed RNA polymerase III subunit B antibody

  • DNA-directed RNA polymerase III 127.6 kDa polypeptide antibody
  • DNA-directed RNA polymerase III subunit B antibody
  • DNA-directed RNA polymerase III subunit RPC2 antibody
  • FLJ10388 antibody
  • polr3b antibody
  • Polymerase (RNA) III (DNA directed) polypeptide B antibody
  • RNA polymerase III subunit C2 antibody
  • RNA polymerase III subunit RPC2 antibody
  • RPC2 antibody
  • RPC2_HUMAN antibody

  see all