製品の概要

  • 製品名Anti-POLE antibody
    POLE 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to POLE
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from an internal region of Human POLE.

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Participates in DNA repair and in chromosomal DNA replication.
  • 配列類似性Belongs to the DNA polymerase type-B family.
  • ドメインThe DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CRCS12 antibody
    • DKFZp434F222 antibody
    • DNA polymerase epsilon catalytic subunit A antibody
    • DNA polymerase epsilon catalytic subunit antibody
    • DNA polymerase II subunit A antibody
    • DPOE1_HUMAN antibody
    • EC 2.7.7.7 antibody
    • FILS antibody
    • FLJ21434 antibody
    • POLE antibody
    • POLE1 antibody
    • Polymerase (DNA directed) epsilon antibody
    • polymerase (DNA directed), epsilon, catalytic subunit antibody
    see all

Anti-POLE antibody 画像

  • ab110876, at a 1/50 dilution, staining POLE in paraffin embedded Human breast carcinoma tissue by Immunohistochemistry, in the absence (left panel) or presence (right panel) of the immunizing peptide.

Anti-POLE antibody (ab110876) 使用論文

This product has been referenced in:
  • Elsayed FA  et al. Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. Eur J Hum Genet N/A:N/A (2014). Read more (PubMed: 25370038) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab110876.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"