製品の概要

  • 製品名Anti-PMS1 antibody
    PMS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PMS1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 693-722 of Human PMS1 (NP_000525.1).

  • ポジティブ・コントロール
    • A549 cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123883 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab123883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 106 kDa.

ターゲット情報

  • 機能Probably involved in the repair of mismatches in DNA.
  • 関連疾患Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3) [MIM:600258]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
  • 配列類似性Belongs to the DNA mismatch repair mutL/hexB family.
    Contains 1 HMG box DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DNA mismatch repair protein PMS1 antibody
    • FLJ98259 antibody
    • HNPCC3 antibody
    • hPMS1 antibody
    • Human homolog of yeast mutL antibody
    • Mismatch repair gene PMSL1 antibody
    • pms1 antibody
    • PMS1 postmeiotic segregation increased 1 (S. cerevisiae) antibody
    • PMS1 postmeiotic segregation increased 1 antibody
    • PMS1 protein homolog 1 antibody
    • PMS1_HUMAN antibody
    • PMSL1 antibody
    • Rhabdomyosarcoma antigen MU RMS 40.10B antibody
    • Rhabdomyosarcoma antigen MU RMS 40.10E antibody
    see all

Anti-PMS1 antibody 画像

  • Anti-PMS1 antibody (ab123883) at 1/100 dilution + A549 cell line lysate at 35 µg

    Predicted band size : 106 kDa

Anti-PMS1 antibody (ab123883) 使用論文

ab123883 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"