製品の概要

  • 製品名
    (±)-SKF38393 hydrochloride
  • 製品の詳細
    D1-like dopamine receptor agonist
  • 生理活性の詳細
    D1-like dopamine receptor agonist. pKi values are 9 (D1), 6.8 (D2), 5.3 (D3), 6.0 (D4) and 9.3 (D5). Ki values are 151 and 2364 nM for D1-like and D2-like dopamine receptors, respectively. Centrally active upon systemic administration.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Manrique-Maldonado G  et al. The dopamine receptors mediating inhibition of the sympathetic vasopressor outflow in pithed rats: pharmacological correlation with the D(2) -like type. Basic Clin Pharmacol Toxicol 109:506-12 (2011). Read more (PubMed: 21740529) »
  • Clark AH  et al. Assessment of dopamine D1 receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorg Med Chem 19:5420-31 (2011). Read more (PubMed: 21862338) »
  • Flournoy WS  et al. Pharmacologic identification of putative D1 dopamine receptors in feline kidneys. J Vet Pharmacol Ther 26:283-90 (2003). Read more (PubMed: 12887611) »
  • Huang KX & Walters JR Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output. J Pharmacol Exp Ther 271:1434-43 (1994). Read more (PubMed: 7996456) »

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