Anti-PLGF 抗体 [RM0010-8F09] (ab51654)
Key features and details
- Rat monoclonal [RM0010-8F09] to PLGF
- Suitable for: WB, IHC-P
- Reacts with: Mouse
- Isotype: IgG2
製品の概要
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製品名
Anti-PLGF antibody [RM0010-8F09]
PLGF 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0010-8F09] to PLGF -
由来種
Rat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant full length protein (Mouse)
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ポジティブ・コントロール
- WB: Mouse embryonic tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
ab51654 was produced from a hybridoma. The IgG fraction of the tissue culture supernatant was purified by Protein G affinity chromatography and lyophilized. -
ポリ/モノ
モノクローナル -
クローン名
RM0010-8F09 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab51654の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/400 - 1/1000. Predicted molecular weight: 17 kDa.
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IHC-P |
1/50 - 1/100.
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特記事項 |
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WB
1/400 - 1/1000. Predicted molecular weight: 17 kDa. |
IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. -
組織特異性
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. -
配列類似性
Belongs to the PDGF/VEGF growth factor family. -
ドメイン
Isoform PlGF-2 contains a basic insert which acts as a cell retention signal. -
翻訳後修飾
N-glycosylated. -
細胞内局在
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. - Information by UniProt
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参照データベース
- Entrez Gene: 18654 Mouse
- SwissProt: P49764 Mouse
- Unigene: 4809 Mouse
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別名
- D12S1900 antibody
- Pgf antibody
- PGFL antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (5)
ab51654 は 5 報の論文で使用されています。
- Crespo-Garcia S et al. Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). PLoS One 13:e0193961 (2018). PubMed: 29547662
- Li X et al. Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. J Cell Mol Med 21:2370-2385 (2017). PubMed: 28378526
- Li Y et al. Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice. Nutrients 7:6425-45 (2015). WB ; Mouse . PubMed: 26247969
- Saad AF et al. Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia. Reprod Sci 21:138-45 (2014). Mouse . PubMed: 23749761
- Tayade C et al. Genetic deletion of placenta growth factor in mice alters uterine NK cells. J Immunol 178:4267-75 (2007). IHC-P ; Mouse . PubMed: 17371983