製品の概要

  • 製品名Anti-Platelet antibody [AIP21]
  • 製品の詳細
    Rat monoclonal [AIP21] to Platelet
  • 特異性ab112238 detects an unidentified antigen on mouse platelets that is not identical to CD9, GPIV or integrins. This antigen is also present on B16F10 and KN-3 cells, but not thymocytes or splenocytes.
  • アプリケーション適用あり: Functional Studies, Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Mouse Platelets

  • 特記事項


    ab112238 induces mouse platelet aggregation in the absence of plasma components via an FcR-independent mechanism. A dramatic increase in tyrosine phosphorylation of the 52 kDa Shc protein was observed during AIP21-mediated platelet aggregation.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 一次抗体 備考ab112238 induces mouse platelet aggregation in the absence of plasma components via an FcR-independent mechanism. A dramatic increase in tyrosine phosphorylation of the 52 kDa Shc protein was observed during AIP21-mediated platelet aggregation.
  • ポリ/モノモノクローナル
  • クローン名AIP21
  • アイソタイプIgM
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab112238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use 1µg for 106 cells. ab35768-Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 関連性Platelets or thrombocytes are the blood cell fragments that are involved in the cellular mechanisms that lead to the formation of blood clots. Low levels or dysfunction predisposes for bleeding, while high levels, although usually asymptomatic, may increase the risk of thrombosis. Like red blood cells, platelets are anuclear (no cell nucleus) and discoid (disc shaped); they measure 1.5 to 3.0 µm in diameter. The body has a very limited reserve of platelets, so they can be rapidly depleted. They contain RNA, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP, ATP serotonin and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released upon activation of the platelet. These granule contents play an important role in both hemostasis and in the inflammatory response.

Anti-Platelet antibody [AIP21] (ab112238) 使用論文

This product has been referenced in:
  • Kato Y  et al. A novel anti-platelet monoclonal antibody induces mouse platelet aggregation through an Fc receptor-independent mechanism. Biochem Biophys Res Commun 242:250-5 (1998). Read more (PubMed: 9446779) »

See 1 Publication for this product

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For ab112238: DISCOUNT CODE: ***
For ab115679: DISCOUNT CODE: ***
Expiration date: November 19, 2012

I am very pleased to hear you would like to accept our offer and test ab112238 for use in ELISA and ab115679 for use in mouse.Each c...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"