The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 88 kDa).
機能May play a role in junctional plaques.
組織特異性Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
関連疾患Familial arrhythmogenic right ventricular dysplasia 9
配列類似性Belongs to the beta-catenin family. Contains 8 ARM repeats.
細胞内局在Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.