製品の概要

  • 製品名Anti-PLA2G4D antibody
    PLA2G4D 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PLA2G4D
  • 特異性Detects endogenous levels of total PLA2G4D protein.
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence of Human PLA2G4D.

  • ポジティブ・コントロール
    • Human brain tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
    Note: PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab111126 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab111126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
  • 組織特異性Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.
  • 配列類似性Contains 1 C2 domain.
    Contains 1 PLA2c domain.
  • ドメインThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • 細胞内局在Cytoplasm > cytosol. Cytoplasmic vesicle membrane. Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • cPLA2 delta antibody
    • cPLA2-delta antibody
    • cPLA2delta antibody
    • Cytosolic phospholipase A2 delta antibody
    • PA24D_HUMAN antibody
    • Phospholipase A2 group IVD antibody
    • phospholipase A2, group IVD (cytosolic) antibody
    • Pla2g4d antibody
    see all

Anti-PLA2G4D antibody 画像

  • ab111126, at a 1/50 dilution, staining PLA2G4D in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.

Anti-PLA2G4D antibody (ab111126) 使用論文

ab111126 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111126.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"