製品の概要

  • 製品名Anti-PKLR antibody [AT1E3]
    PKLR 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [AT1E3] to PKLR
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 47-574 of Human PKLR, purified from E. coli (NP_000289)

  • ポジティブ・コントロール
    • 293T cell lysate

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab119500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Predicted molecular weight: 62 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Plays a key role in glycolysis.
  • パスウェイCarbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
  • 関連疾患Defects in PKLR are the cause of pyruvate kinase hyperactivity (PKHYP) [MIM:102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.
    Defects in PKLR are the cause of pyruvate kinase deficiency of red cells (PKRD) [MIM:266200]. A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
  • 配列類似性Belongs to the pyruvate kinase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC 2.7.1.40 antibody
    • KPYR_HUMAN antibody
    • L-PK antibody
    • Pk-1 antibody
    • PK1 antibody
    • PKL antibody
    • Pklg antibody
    • Pklr antibody
    • PKR antibody
    • PKRL antibody
    • Pyruvate kinase 1 antibody
    • Pyruvate kinase isozymes R/L antibody
    • Pyruvate kinase liver and blood cell antibody
    • Pyruvate kinase liver and RBC antibody
    • Pyruvate kinase liver and red blood cell antibody
    • Pyruvate kinase liver type antibody
    • Pyruvate kinase type L antibody
    • Pyruvate kinase, red cell type antibody
    • R type/L type pyruvate kinase antibody
    • R-PK antibody
    • R-type/L-type pyruvate kinase antibody
    • Red cell/liver pyruvate kinase antibody
    • RPK antibody
    see all

Anti-PKLR antibody [AT1E3] 画像

  • Anti-PKLR antibody [AT1E3] (ab119500) at 1/500 dilution + 293T cell lysate at 40 µg

    Secondary
    goat anti-mouse HRP
    Developed using the ECL technique

    Predicted band size : 62 kDa
    Observed band size : 62 kDa

Anti-PKLR antibody [AT1E3] (ab119500) 使用論文

ab119500 has not yet been referenced specifically in any publications.

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