Anti-PKC delta (phospho Y313) 抗体 (ab62202)

製品の概要

  • 製品名
    Anti-PKC delta (phospho Y313) antibody
    PKC delta 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PKC delta (phospho Y313)
  • 特異性
    ab62202 detects endogenous levels of PKC delta only when phosphorylated at tyrosine 313 (human) (tyrosine 311 (mouse, rat)).
  • アプリケーション
    適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from around the phosphorylation site of tyrosine 313 (GIYPQG) of human PKC delta

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100.
ELISA 1/10000.

ターゲット情報

  • 機能
    This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
  • 配列類似性
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 C2 domain.
    Contains 2 phorbol-ester/DAG-type zinc fingers.
    Contains 1 protein kinase domain.
  • ドメイン
    The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
    The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
  • 翻訳後修飾
    Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity.
  • 細胞内局在
    Cytoplasm. Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CVID9 antibody
    • D14Ertd420e antibody
    • Kinase PKC delta antibody
    • KPCD antibody
    • KPCD_HUMAN antibody
    • MAY 1 antibody
    • MAY1 antibody
    • MGC49908 antibody
    • nPKC delta antibody
    • nPKC-delta antibody
    • PCKd antibody
    • PKC d antibody
    • PKC delta antibody
    • PKCD antibody
    • PKCdelta antibody
    • PRKC D antibody
    • PRKC delta antibody
    • Prkcd antibody
    • Protein Kinase C delta antibody
    • Protein kinase C delta type antibody
    • Protein kinase C delta VIII antibody
    • Protein Kinase Cdelta antibody
    • Tyrosine protein kinase PRKCD antibody
    see all

画像

  • All lanes : Anti-PKC delta (phospho Y313) antibody (ab62202)

    Lane 1 : HUVEC cell lysate
    Lane 2 : COLO cell lysate
    Lane 3 : HepG2 cell lysate
    Lane 4 : HUVEC cell lysate with phospho peptide
  • Immunohistochemical analysis staining PKC delta (Phospho Y313) in paraffin embedded human breast carcinoma using ab62202.

プロトコール

参考文献

ab62202 has not yet been referenced specifically in any publications.

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