製品の概要

  • 製品名Anti-PKC alpha + beta 2 antibody
    PKC alpha + beta 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PKC alpha + beta 2
  • 特異性Detects endogenous levels of total PKC alpha/beta 2 protein.
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic non phosphopeptide derived from human PKC alpha/beta 2 around the phosphorylation site of threonine 638 (VLTPPP).

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59328 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/5000.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 関連性Protein kinase C alpha and protein kinase C beta belong to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily. Both contain 1 AGC kinase C terminal domain, 1 C2 domain, 2 phorbol ester/DAG type zinc fingers and 1 protein kinase domain. They are calcium activated, phospholipid dependent, serine and threonine specific enzymes. PKC alpha and may play a role in cell motility. PKC beta may be a novel component of the NF kappa B signaling axis responsible for the survival and activation of B cells after BCR cross linking. Both are activated by diacylglycerol which in turn phosphorylates a range of cellular proteins and both may also serve as the receptor for phorbol esters, a class of tumor promoters. PKC beta has two named isoforms produced by alternative splicing.
  • 細胞内局在Cell Membrane and Cytoplasmic
  • 参照データベース
  • 別名
    • PKC alpha antibody
    • PKC beta antibody
    • PKCA antibody
    • PKCB antibody
    • PRKACA antibody
    • PRKCB antibody
    • PRKCB2 antibody
    • Protein kinase C alpha type antibody
    • Protein kinase C beta antibody
    • Protein kinase C beta type antibody
    • protein kinase C, alpha antibody
    see all

Anti-PKC alpha + beta 2 antibody 画像

  • ab59328 at 1/50 dilution staining human breast carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-PKC alpha + beta 2 antibody (ab59328) 使用論文

ab59328 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"