Anti-PKA beta (catalytic subunit) (phospho T198) 抗体 (ab118531)

製品の概要

  • 製品名Anti-PKA beta (catalytic subunit) (phospho T198) antibody
    PKA beta (catalytic subunit) 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PKA beta (catalytic subunit) (phospho T198)
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Sheep, Cow, Pig, Caenorhabditis elegans, Drosophila melanogaster
  • 免疫原

    Synthetic phosphopeptide, conjugated to KLH, corresponding to amino acids 193-202 of Human PKA beta (catalytic subunit) with phosphoThr at position 198 (NP_002722.1).

  • ポジティブ・コントロール
    • Human Kidney tissue.

法規制情報

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
  • 組織特異性Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
  • 配列類似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
  • 細胞内局在Cytoplasm. Nucleus. Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody
    • cAMP-dependent protein kinase catalytic subunit beta antibody
    • KAPCB_HUMAN antibody
    • PKA C beta antibody
    • PKA C-beta antibody
    • PKACB antibody
    • Prkacb antibody
    • protein kinase A catalytic subunit beta antibody
    • Protein kinase cAMP dependent catalytic beta antibody
    see all

Anti-PKA beta (catalytic subunit) (phospho T198) antibody 画像

  • Human Kidney tissue (formalin-fixed, paraffin-embedded) stained with ab118531 at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PKA beta (catalytic subunit) (phospho T198) antibody (ab118531) 使用論文

ab118531 has not yet been referenced specifically in any publications.

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