Anti-PKA beta (catalytic subunit) 抗体 (ab94612)

製品の概要

• 製品名
  Anti-PKA beta (catalytic subunit) antibody
  PKA beta (catalytic subunit) 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to PKA beta (catalytic subunit)
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Caenorhabditis elegans, Drosophila melanogaster, Zebrafish
• 免疫原

  Synthetic peptide corresponding to a region within the internal sequence amino acids 288-337 (GVSDIKTHKW FATTDWIAIY QRKVEAPFIP KFRGSGDTSN FDDYEEEDIR) of Human PKA beta (catalytic subunit)(NP_002722).

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human fetal lung lysate

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab94612 is purified by peptide affinity chromatography method.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • PKA

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
• 組織特異性
  Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
• 配列類似性
  Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
  Contains 1 AGC-kinase C-terminal domain.
  Contains 1 protein kinase domain.
• 翻訳後修飾
  Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
• 細胞内局在
  Cytoplasm. Nucleus. Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.

• Target information above from: UniProt accession P22694 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 5567 Human
  • Entrez Gene: 18749 Mouse
  • Entrez Gene: 293508 Rat
  • Omim: 176892 Human
  • SwissProt: P05131 Cow
  • SwissProt: Q8MJ44 Dog
  • SwissProt: P22694 Human
  • SwissProt: P68181 Mouse

  • SwissProt: P05383 Pig
  • SwissProt: P68182 Rat
  • SwissProt: Q9MZD9 Sheep
  • Unigene: 487325 Human
  • Unigene: 16766 Mouse
  • Unigene: 202491 Rat

  see all
• 別名
  • cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody
  • cAMP-dependent protein kinase catalytic subunit beta antibody
  • KAPCB_HUMAN antibody

  • PKA C beta antibody
  • PKA C-beta antibody
  • PKACB antibody
  • Prkacb antibody
  • protein kinase A catalytic subunit beta antibody
  • Protein kinase cAMP dependent catalytic beta antibody

  see all

プロトコール

• Western blot protocols