製品の概要

  • 製品名Pitstop® 1
  • 製品の詳細
    Novel, selective clathrin inhibitor
  • 生理活性の詳細Novel, selective clathrin inhibitor. Competitively inhibits clathrin terminal domain (TD) to selectively inhibit clathrin mediated endocytosis (IC50 = ~18 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis, entry of HIV and synaptic vesicle recycling. Exhibits limited cell membrane penetration, however it is active in cells after microinjection.
  • 特記事項Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute

製品の特性

    Pitstop® 1 (ab120685) 使用論文

    This product has been referenced in:
    • von Kleist L  et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146:471-84 (2011). Read more (PubMed: 21816279) »

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