製品の概要

  • 製品名Anti-PITRM1 antibody
    PITRM1 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to PITRM1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human PITRM1 protein (AAH95422.1).

  • ポジティブ・コントロール
    • PITRM1 transfected 293T lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: Whole serum
  • 精製度Whole antiserum
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab68502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 117 kDa (predicted molecular weight: 117 kDa).

ターゲット情報

  • 機能ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
  • 組織特異性Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
  • 配列類似性Belongs to the peptidase M16 family. PreP subfamily.
  • 翻訳後修飾The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hMP1 antibody
    • hPreP antibody
    • KIAA1104 antibody
    • Metalloprotease 1 antibody
    • MGC138192 antibody
    • MGC141929 antibody
    • mitochondrial antibody
    • MP1 antibody
    • Pitrilysin metallopeptidase 1 antibody
    • Pitrilysin metalloproteinase 1 antibody
    • PITRM 1 antibody
    • PITRM1 antibody
    • PreP antibody
    • PreP peptidasome antibody
    • PREP_HUMAN antibody
    • Presequence protease antibody
    • Presequence protease mitochondrial antibody
    see all

Anti-PITRM1 antibody 画像

  • All lanes : Anti-PITRM1 antibody (ab68502) at 1/500 dilution

    Lane 1 : PITRM1 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 117 kDa
    Observed band size : 117 kDa

Anti-PITRM1 antibody (ab68502) 使用論文

ab68502 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab68502.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"