Pirenzepine dihydrochloride, M1 antagonist (ab120153)
Key features and details
- M1 antagonist
- CAS Number: 29868-97-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Pirenzepine dihydrochloride, M1 antagonist -
製品の詳細
M1 antagonist -
生理活性の詳細
Selective M1 receptor antagonist.
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CAS 番号
29868-97-1 -
構造式
製品の特性
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体系名
5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride -
分子量
424.32 -
分子式
C19H21N5O2.2HCl -
PubChem 登録番号
71405 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.Cl.O=C(CN1CCN(C)CC1)N4c2ccccc2C(=O)Nc3cccnc34 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120153 は 4 報の論文で使用されています。
- Hu NW et al. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun 5:3374 (2014). PubMed: 24594908
- Barrett SG & Chapman CA Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex. Neurosci Lett 554:11-5 (2013). PubMed: 24012918
- Glasgow SD et al. Cholinergic suppression of excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience 201:1-11 (2012). PubMed: 22138154
- Gorini C et al. Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors. J Neurophysiol 104:1841-8 (2010). PubMed: 20719927