Anti-PIP5KI gamma 抗体 - N-terminal (ab71820)

製品の概要

  • 製品名Anti-PIP5KI gamma antibody - N-terminal
    PIP5KI gamma 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PIP5KI gamma - N-terminal
  • アプリケーション適用あり: ELISA, IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • ポジティブ・コントロール
    • 293 cell lysate and human hepatocarcinoma tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)ab71820 is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab71820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/50 - 1/100.
WB 1/100 - 1/500. Detects a band of approximately 70 kDa (predicted molecular weight: 74 kDa).

ターゲット情報

  • 機能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
  • 関連疾患Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
  • 配列類似性Contains 1 PIPK domain.
  • 細胞内局在Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Diphosphoinositide kinase antibody
    • LCCS3 antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
    • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
    • PI51C antibody
    • PI51C_HUMAN antibody
    • PIP5K GAMMA antibody
    • PIP5K1-gamma antibody
    • Pip5k1c antibody
    • PIP5KIgamma antibody
    • PtdIns(4)P 5 kinase gamma antibody
    • PtdIns(4)P-5-kinase 1 gamma antibody
    • Type I PIP kinase antibody
    see all

Anti-PIP5KI gamma antibody - N-terminal 画像

  • Anti-PIP5KI gamma antibody - N-terminal (ab71820) at 1/100 dilution + 293 cell lysate at 12.5 µg

    Predicted band size : 74 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.
  • ab71820 at 1/50 dilution, staining PIP5KI gamma in human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-PIP5KI gamma antibody - N-terminal (ab71820) 使用論文

ab71820 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"