製品の概要

  • 製品名Anti-PIP5KI gamma antibody [MAO-R1]
    PIP5KI gamma 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [MAO-R1] to PIP5KI gamma
  • アプリケーション適用あり: WB, IPmore details
    適用なし: Flow Cyt,ICC or IHC-P
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Recombinant full length Mouse PIP5KI gamma.

  • ポジティブ・コントロール
    • K562, Human fetal kidney, C6, Neuro-2a, and 293T cell lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

     

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名MAO-R1
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab109192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 80-90 kDa (predicted molecular weight: 73 kDa).
IP 1/10 - 1/100.
  • 追加情報Is unsuitable for Flow Cyt,ICC or IHC-P.
  • ターゲット情報

    • 機能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
    • 関連疾患Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
    • 配列類似性Contains 1 PIPK domain.
    • 細胞内局在Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Diphosphoinositide kinase antibody
      • LCCS3 antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
      • Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody
      • PI51C antibody
      • PI51C_HUMAN antibody
      • PIP5K GAMMA antibody
      • PIP5K1-gamma antibody
      • Pip5k1c antibody
      • PIP5KIgamma antibody
      • PtdIns(4)P 5 kinase gamma antibody
      • PtdIns(4)P-5-kinase 1 gamma antibody
      • Type I PIP kinase antibody
      see all

    Anti-PIP5KI gamma antibody [MAO-R1] 画像

    • All lanes : Anti-PIP5KI gamma antibody [MAO-R1] (ab109192) at 1/1000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : Human fetal kidney cell lysate
      Lane 3 : C6 cell lysate
      Lane 4 : Neuro-2a cell lysate
      Lane 5 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 73 kDa

    Anti-PIP5KI gamma antibody [MAO-R1] (ab109192) 使用論文

    This product has been referenced in:
    • Tojima T  et al. Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis. J Neurosci 34:7165-78 (2014). Read more (PubMed: 24849351) »

    See 1 Publication for this product

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