製品の概要

  • 製品名Anti-PION antibody
    PION 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PION
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 536-565 of Human PION (NP_059135.2).

  • ポジティブ・コントロール
    • NCI-H292 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG

アプリケーション

Our Abpromise guarantee covers the use of ab113024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 98 kDa.

ターゲット情報

  • 機能Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the GSAP family.
  • 翻訳後修飾The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.
  • 細胞内局在Golgi apparatus > trans-Golgi network.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A530088I07Rik antibody
    • DKFZp667B242 antibody
    • Gamma-secretase-activating protein 16 kDa C-terminal form antibody
    • GSAP antibody
    • GSAP-16K antibody
    • GSAP_HUMAN antibody
    • MGC126548 antibody
    • Pigeon homolog (Drosophila) antibody
    • Pion antibody
    • Protein pigeon homolog antibody
    • tcag7.1314 antibody
    see all

Anti-PION antibody 画像

  • Anti-PION antibody (ab113024) at 1/100 dilution + NCI-H292 cell lysate at 35 µg

    Predicted band size : 98 kDa

Anti-PION antibody (ab113024) 使用論文

ab113024 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113024.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"