製品の概要

  • 製品名Anti-PION antibody
    PION 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PION
  • 特異性ab106630 is predicted to not cross-react with other F-box protein family members.
  • アプリケーション適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human PION (C terminal).

  • ポジティブ・コントロール
    • EL4 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab106630 was purified by affinity chromatography via a peptide column.
  • ポリ/モノポリクローナル
  • アイソタイプIgG

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab106630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 98 kDa.

ターゲット情報

  • 機能Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the GSAP family.
  • 翻訳後修飾The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.
  • 細胞内局在Golgi apparatus > trans-Golgi network.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A530088I07Rik antibody
    • DKFZp667B242 antibody
    • Gamma-secretase-activating protein 16 kDa C-terminal form antibody
    • GSAP antibody
    • GSAP-16K antibody
    • GSAP_HUMAN antibody
    • MGC126548 antibody
    • Pigeon homolog (Drosophila) antibody
    • Pion antibody
    • Protein pigeon homolog antibody
    • tcag7.1314 antibody
    see all

Anti-PION antibody 画像

  • All lanes : Anti-PION antibody (ab106630) at 0.25 µg/ml

    Lane 1 : EL4 cell lysate
    Lane 2 : EL4 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 98 kDa
  • Immunofluorescence of PION in Human Brain cells using ab106630 at 20 ug/ml.

Anti-PION antibody (ab106630) 使用論文

ab106630 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your phone call. Yes, ab106630 will detect the 16 kDa active form of PION as long as it is expressed at detectable levels in your samples. I hope this helps, please let me know if you need any additional information.

Thank you for your patience. I just heard back from the lab with the following good news: There is 100% homology between the immunogen for catalog number ab106630 and the sequence provided. I hope this information is helpful to yo...

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Thank you for contacting us. Unfortunately, the exact immunogen sequence is proprietary and we are not able to disclose it. However, if you please could send me the sequence of the 16 kDa C-terminal fragment of PION that you would like ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"